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dc.contributor.author
Marani, Mariela Mirta
dc.contributor.author
Dourado, Flávio Santos
dc.contributor.author
Quelemes, Patrick Veras
dc.contributor.author
Araujo, Alyne Rodrigues de
dc.contributor.author
Perfeito, Márcia Luana Gomes
dc.contributor.author
Barbosa, Eder Alves
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Véras, Leiz Maria Costa
dc.contributor.author
Coelho, Andreia Luísa Rodrigues
dc.contributor.author
Andrade, Etielle Barroso
dc.contributor.author
Eaton, Peter
dc.contributor.author
Longo, João Paulo Figueiró
dc.contributor.author
Azevedo, Ricardo Bentes
dc.contributor.author
Matos, Cristina Delerue
dc.contributor.author
Leite, José Roberto S. A.
dc.date.available
2017-06-30T15:05:46Z
dc.date.issued
2015-06-24
dc.identifier.citation
Marani, Mariela Mirta; Dourado, Flávio Santos; Quelemes, Patrick Veras; Araujo, Alyne Rodrigues de; Perfeito, Márcia Luana Gomes; et al.; Characterization and biological activities of ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus; American Chemical Society; Journal Of Natural Products; 78; 7; 24-6-2015; 1495-1504
dc.identifier.issn
0163-3864
dc.identifier.uri
http://hdl.handle.net/11336/19254
dc.description.abstract
Eight new peptides were isolated from the skin secretion of the frog Leptodactylus pustulatus and their amino acid sequences determined by de novo sequencing and by cDNA cloning. Structural similarities between them and other antimicrobial peptides from the skin secretion of Leptodactylus genus frogs were found. Ocellatins-PT1 to -PT5 (25 amino acid residues) are amidated at the C-terminus, while ocellatins-PT6 to -PT8 (32 amino acid residues) have free carboxylates. Antimicrobial activity, hemolytic tests, and cytotoxicity against a murine fi broblast cell line were investigated. All peptides, except for ocellatin-PT2, have antimicrobial activity against at least one Gram-negative strain. Ocellatin-PT8 inhibited the growth of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Salmonella choleraesuis strains with MICs in the 60 − 240 μ M range. No signi fi cant e ff ect was observed in human erythrocytes and in a murine fi broblast cell line after exposure to the peptides at MICs. A comparison between sequences obtained by both direct HPLC-MS de novo sequencing and cDNA cloning demonstrates the secretion of mature peptides derived from a pre-pro-peptide structure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Peptidos
dc.subject
Antimicrobianos
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Bioprospección
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Anfibios
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Characterization and biological activities of ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-04-28T14:51:50Z
dc.journal.volume
78
dc.journal.number
7
dc.journal.pagination
1495-1504
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
dc.description.fil
Fil: Dourado, Flávio Santos. Secretaria de Vigilancia em Saude, Ministerio da Saude; Brasil
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Fil: Quelemes, Patrick Veras. Universidade Federal do Piauí; Brasil
dc.description.fil
Fil: Araujo, Alyne Rodrigues de. Universidade Federal do Piauí; Brasil
dc.description.fil
Fil: Perfeito, Márcia Luana Gomes. Universidade Federal do Piauí; Brasil
dc.description.fil
Fil: Barbosa, Eder Alves. Universidade Do Brasilia; Brasil
dc.description.fil
Fil: Véras, Leiz Maria Costa. Universidade Federal do Piauí; Brasil
dc.description.fil
Fil: Coelho, Andreia Luísa Rodrigues. Universidade Federal do Piauí; Brasil. Instituto Superior de Engenharia do Instituto Politécnico do Porto; Portugal
dc.description.fil
Fil: Andrade, Etielle Barroso. Universidade Federal do Piauí; Brasil. Universidade Federal do Maranhaõ; Brasil
dc.description.fil
Fil: Eaton, Peter. Universidade do Porto; Portugal
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Fil: Longo, João Paulo Figueiró. Universidade Do Brasilia; Brasil
dc.description.fil
Fil: Azevedo, Ricardo Bentes. Universidade Do Brasilia; Brasil
dc.description.fil
Fil: Matos, Cristina Delerue. Instituto Superior de Engenharia do Instituto Politécnico do Porto; Portugal
dc.description.fil
Fil: Leite, José Roberto S. A.. Universidade Federal do Piauí; Brasil
dc.journal.title
Journal Of Natural Products
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/np500907t
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/np500907t
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