Artículo
Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations
Fecha de publicación:
12/2014
Editorial:
Instituto de Física de Líquidos y Sistemas Biológicos
Revista:
Papers in Physics
ISSN:
1852-4249
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the number of bound repressors affects transcription rate. Effective Hill exponents of the resulting regulatory functions reveal an increase in the nonlinearity of the feedback with the number of binding sites. We identify optimal configurations that maximize the nonlinearity of the feedback. We use a generic model of a biochemical oscillator to show that this increased nonlinearity is reflected in enhanced oscillations, with larger amplitudes over wider oscillatory ranges. Although the study is motivated by genetic oscillations in the zebrafish segmentation clock, our findings may reveal a general principle for gene regulation.
Palabras clave:
Negative Feedback
,
Genetic Oscillations
,
Nonlinear Dynamics
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Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Citación
Lengyel, Iván Miguel; Soroldoni, Daniele; Oates, Andrew C.; Morelli, Luis Guillermo; Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations; Instituto de Física de Líquidos y Sistemas Biológicos; Papers in Physics; 6; 12-2014; 1-11; 060012
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