Artículo
Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk
Fecha de publicación:
01/2012
Editorial:
Elsevier
Revista:
Toxicon
ISSN:
0041-0101
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by depurinating an adenine on the sarcin–ricin loop (SRL) of the large subunit ribosomal RNA. Several RIPs interact with the C-terminal end of ribosomal stalk P proteins, and this interaction is required for their full activity. In contrast, the activity of Pokeweed Antiviral Protein is not affected by blocking this stalk component. Here, we provide evidence from phylogenetic analyses and sequence alignments suggesting that the interaction with the C-terminal end of P proteins evolved independently in different RIPs by convergent evolution.
Palabras clave:
Ribosome Inactivating Proteins
,
Stalk
,
Phylogeny
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBAM)
Articulos de INST.DE BIOLOGIA AGRICOLA DE MENDOZA
Articulos de INST.DE BIOLOGIA AGRICOLA DE MENDOZA
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Lapadula, Walter Jesús; Sanchez Puerta, Maria Virginia; Juri Ayub, Maximiliano; Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk; Elsevier; Toxicon; 59; 3; 1-2012; 427-432
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