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dc.contributor.author Urtreger, Alejandro Jorge
dc.contributor.author Kazanietz, Marcelo G.
dc.contributor.author Bal, Elisa Dora
dc.date.available 2017-03-20T20:51:41Z
dc.date.issued 2012-01
dc.identifier.citation Urtreger, Alejandro Jorge; Kazanietz, Marcelo G. ; Bal, Elisa Dora; Contribution of individual PKC isoforms to breast cancer progression; Wiley; IUBMB Life; 64; 1; 1-2012; 18-26
dc.identifier.issn 1521-6543
dc.identifier.uri http://hdl.handle.net/11336/14122
dc.description.abstract The protein kinase C (PKC) family of serine/threonine kinases has been intensively studied in cancer since their discovery as major receptors for the tumor-promoting phorbol esters. The contribution of each individual PKC isozyme to malignant transformation is only partially understood, but it is clear that each PKC plays different role in cancer progression. PKC deregulation is a common phenomenon observed in breast cancer, and PKC expression and localization are usually dynamically regulated during mammary gland differentiation and involution. In fact, the overexpression of several PKCs has been reported in malignant human breast tissue and breast cancer cell lines. In this review, we summarize the knowledge available on the specific roles of PKC isoforms in the development, progression, and metastatic dissemination of mammary cancer. We also discuss the role of PKC isoforms as therapeutic targets, and their potential as markers for prognosis or treatment response.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject PROTEIN KINASE C
dc.subject BREAST CANCER
dc.subject TUMOR PROGRESSION
dc.subject PROGNOSTIC MARKER
dc.subject.classification Otros Tópicos Biológicos
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Contribution of individual PKC isoforms to breast cancer progression
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-20T17:41:16Z
dc.journal.volume 64
dc.journal.number 1
dc.journal.pagination 18-26
dc.journal.pais Estados Unidos
dc.journal.ciudad Hoboken
dc.description.fil Fil: Urtreger, Alejandro Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina
dc.description.fil Fil: Kazanietz, Marcelo G. . University of Pennsylvania; Estados Unidos
dc.description.fil Fil: Bal, Elisa Dora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncologia "Angel H. Roffo"; Argentina
dc.journal.title IUBMB Life
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/iub.574/full
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/iub.574


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)