Artículo
Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents
Caputto, Maria Eugenia
; Fabian, Lucas Emanuel
; Benítez, Diego; Merlino, Alicia; Ríos, Natalia; Cerecetto, Hugo; Moltrasio, Graciela Y.; Moglioni, Albertina Gladys
; González, Mercedes; Finkielsztein, Liliana M.
Fecha de publicación:
11/2011
Editorial:
Elsevier
Revista:
Bioorganic
ISSN:
0968-0896
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In the present work, we synthesized a series of thiosemicarbazones derived from 1-indanones with good anti-Trypanosoma cruzi activity. Most of them displayed remarkable trypanosomicidal activity. All the compounds showed nonspecific cytotoxicity on human erythrocytes. The ability of the new compounds to inhibit cruzipain, the major cysteine protease of T. cruzi, was also explored. Thiosemicarbazones 12 and 24 inhibited this enzyme at the dose assayed. This interaction was also studied in terms of molecular docking.
Palabras clave:
Thiosemicarbazones
,
Anti-Trypanosoma Cruzi Agents
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Caputto, Maria Eugenia; Fabian, Lucas Emanuel; Benítez, Diego; Merlino, Alicia; Ríos, Natalia; et al.; Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents; Elsevier; Bioorganic; 19; 22; 11-2011; 6818-6826
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