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dc.contributor.author García Fulgueiras, Virginia
dc.contributor.author Bado, Inés
dc.contributor.author Mota, María Inés
dc.contributor.author Robino, Luciana
dc.contributor.author Cordeiro, Nicolás F.
dc.contributor.author Varela, Adriana
dc.contributor.author Algorta, Gabriela
dc.contributor.author Gutkind, Gabriel Osvaldo
dc.contributor.author Ayala, Juan A.
dc.contributor.author Vignoli, Rafael
dc.date.available 2017-02-13T20:21:50Z
dc.date.issued 2011-08
dc.identifier.citation García Fulgueiras, Virginia; Bado, Inés; Mota, María Inés; Robino, Luciana; Cordeiro, Nicolás F.; et al.; Extended-spectrum β-lactamases and plasmid-mediated quinolone resistance in enterobacterial clinical isolates in the paediatric hospital of Uruguay; Oxford University Press; Journal of Antimicrobial Chemotherapy; 66; 8; 8-2011; 1725-1729
dc.identifier.issn 0305-7453
dc.identifier.uri http://hdl.handle.net/11336/12923
dc.description.abstract Objectives To analyse the prevalence of resistance to β-lactams and plasmid-mediated quinolone resistance in Enterobacteriaceae in the paediatric hospital of Uruguay. Methods A total of 368 enterobacterial isolates collected between 1 May and 30 November 2009 were studied for the presence of extended-spectrum β-lactamases (ESBLs), qnr alleles and aac(6′)Ib by phenotypic and molecular methods. The genomic context and transferability of β-lactamase and qnr genes were examined by PCR and conjugation, respectively. Results The proportion of inpatients having an infection caused by ESBL-producing enterobacteria was 0.23% (16/7073) in paediatrics wards, 0.64‰ (3/4696) in the neonatology department and 0.03‰ (1/32 557) in the emergency department. ESBL-carrying enterobacteria constituted a total of 21.6% (16/74), 13% (3/23) and 0.37% (1/271) when samples were obtained from paediatrics wards, the neonatology department and the emergency department, respectively. Overall, CTX-M-2 (n = 7), CTX-M-9 (n = 3), CTX-M-8 (n = 2), CTX-M-15 (n = 1), SHV-5 (n = 5) and SHV-2 (n = 2) β-lactamases were detected. Thirteen out of 20 ESBL-producing isolates also carried the aac(6′)Ib gene, and the cr variant was detected in one of them. qnr alleles were detected in four isolates comprising two qnrA1 genes, a qnrB8-like variant and a new qnrB gene showing 26 amino acid differences from QnrB1. Conclusions The proportion of ESBL-producing enterobacteria in Uruguay's paediatric hospital during the study period was 2.3 per 1000 hospitalized patients. The number of different microorganisms detected, as well as the various EBSLs, suggests the occurrence of sporadic episodes instead of nosocomial outbreaks. Nevertheless, the presence of new resistance genes reinforces the necessity for permanent surveillance programmes.
dc.format application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ANTIBIOTIC RESISTANCE
dc.subject ENTEROBACTERIACEAE
dc.subject INTEGRONS
dc.subject.classification Enfermedades Infecciosas
dc.subject.classification Ciencias de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Extended-spectrum β-lactamases and plasmid-mediated quinolone resistance in enterobacterial clinical isolates in the paediatric hospital of Uruguay
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-02-09T18:23:22Z
dc.journal.volume 66
dc.journal.number 8
dc.journal.pagination 1725-1729
dc.journal.pais Reino Unido
dc.journal.ciudad Oxford
dc.description.fil Fil: García Fulgueiras, Virginia. Universidad de la Republica; Uruguay
dc.description.fil Fil: Bado, Inés. Universidad de la Republica; Uruguay
dc.description.fil Fil: Mota, María Inés. Universidad de la Republica; Uruguay. Uruguay. Ministerio de Salud Pública; Uruguay
dc.description.fil Fil: Robino, Luciana. Universidad de la Republica; Uruguay
dc.description.fil Fil: Cordeiro, Nicolás F.. Universidad de la Republica; Uruguay
dc.description.fil Fil: Varela, Adriana. Uruguay. Ministerio de Salud Pública; Uruguay
dc.description.fil Fil: Algorta, Gabriela. Universidad de la Republica; Uruguay. Uruguay. Ministerio de Salud Pública; Uruguay
dc.description.fil Fil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
dc.description.fil Fil: Ayala, Juan A.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Cientificas; España
dc.description.fil Fil: Vignoli, Rafael. Universidad de la Republica; Uruguay
dc.journal.title Journal of Antimicrobial Chemotherapy
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkr222
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/jac/dkr222


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)