Artículo
Endocarditis caused by methicillin-susceptible Staphylococcus aureus with reduced susceptibility to vancomycin: a case report
Perazzi, Beatriz; Bello, Natalia; Mollerach, Marta Eugenia
; Vay, Carlos; Lasala, María Beatriz; Famiglietti, Angela
Fecha de publicación:
07/2011
Editorial:
BioMed Central Home
Revista:
Journal of Medical Case Reports
ISSN:
1752-1947
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Staphylococcus aureus is the most common cause of acute infective endocarditis.
Recent reports have described heteroresistance to vancomycin associated with methicillin-resistant Staphylococcus aureus. We present the first case report in Argentina of the failure of treatment with vancomycin in endocarditis caused by methicillin-susceptible Staphylococcus aureus containing subpopulations with reduced susceptibility to vancomycin.
Case presentation: We report the case of a 66-year-old Hispanic man with infective endocarditis complicated by septic emboli in the lumbosacral spine and the left iliopsoas muscle. This disease was caused by methicillin susceptible
Staphylococcus aureus containing subpopulations with reduced susceptibility to vancomycin. He was initially treated with cephalothin and gentamicin but developed a rash caused by beta-lactams and interstitial nephritis. For that reason, the treatment was subsequently switched to vancomycin but he failed to respond. The
infection resolved after administration of vancomycin in combination with gentamicin and rifampin.
Conclusion: Our case report provides important evidence for the existence of subpopulations of methicillin susceptible Staphylococcus aureus that have reduced susceptibility to vancomycin which would account for treatment failure. Our case raises an alert about the existence of these strains and highlights the need to
determine the vancomycin minimum inhibitory concentration of Staphylococcus aureus to screen for the presence of strains that have reduced vancomycin susceptibility at different infection sites.
Palabras clave:
Staphylococcus Aureus
,
Vancomicina
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Perazzi, Beatriz; Bello, Natalia; Mollerach, Marta Eugenia; Vay, Carlos; Lasala, María Beatriz; et al.; Endocarditis caused by methicillin-susceptible Staphylococcus aureus with reduced susceptibility to vancomycin: a case report; BioMed Central Home; Journal of Medical Case Reports; 5; 7-2011; 292-298
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